An idea that might seem outlandish at first is gaining some ground as a way to speed development of a coronavirus vaccine: intentionally infecting people with the virus as part of a trial.
The idea, known as a “challenge trial,” would deliberately infect a few hundred young, healthy volunteers, who were first given either the potential vaccine or a placebo. Those picked would be well informed about the risks.
That would allow the effectiveness of a vaccine to be determined faster than a traditional clinical trial, which would require that researchers wait for some of the participants to become infected in the course of their daily lives. Continue reading.